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KMID : 0356420030210020103
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Journal of Korean Andrology
2003 Volume.21 No. 2 p.103 ~ p.110
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Protective Effect of Capsaicin on Contralateral Testis of Rats during Unilateral Testicular Torsion
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Lee Seong-Ho
Moon Ki-Hak
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Abstract
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Purpose: Unilateral testicular torsion is usually associated with damaged to both the affected and the contralateral testic and thus with diminished fertility. This study was preformed to evaluate whether the capsaicin prevents contralateral testicular damage and how long the protection lasts.
Materials and Methods: Eight groups of 8 male Sprague-Dawley rats (5 weeks old ; 150~180 g) were studied. Groups 1 and 5 were sham-operated controls, groups 2 and 6 were testicular torsion controls, groups 3 and 7 underwent sham operation 24 hours after intraperitoneal adminstration of 0.5 cm³of capsaicin, and groups 4 and 8 had testicular torsion performed 24 hours after the intraperitoneal administration of 0.5 cm³capsaicin. The contralateral testis of each animal was harvested at 24 hours after the operation(groups 1~4) or at 4 weeks(groups 5~8). The weight, histologic finding, and extent of apoptosis were evaluated.
Results: At 4 weeks, the weight of the contralateral testis and the diameter of the seminiferous tubules were decreased in the testicular torsion groups. The histologic grade and spermatogenesis was significantly lower in groups 6 and 8. The apoptosis index was significantly higher in groups 2, 6, and 8.
Conclusions: Capsaicin prevents early contralateral testicular damage from unilateral torsion (within 24 hours). However, these effects are not sustained at 4 weeks.
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KEYWORD
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Testicular torsion, Capsaicin, Prevention
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